ABSTRACT The high global burden of cryptococcosis has made development of a protective vaccine a public health priority.We previously demonstrated that a vaccine composed of recombinant Cryptococcus neoformans chitin deacetylase 2 (Cda2) delivered in glucan particles (GPs) protects BALB/c and C57BL/6 mice from an otherwise lethal challenge with a h
Conservation efforts in cliff habitats pose unique challenges due to their inaccessibility, limiting the study and protection of rare endemic species.This project introduces a novel approach utilizing aerial manipulation through a suspended manipulator attached with a cable under a drone to address these challenges.Unlike existing solutions, the Ma
Many persistent viral infections are characterized by a hypofunctional T cell response and the upregulation of negative immune regulators.These events occur days after the initiation of infection.However, the very early host-virus interactions that determine the establishment lcpl chevrons of viral persistence remain poorly uncharacterized.Here we
Mohammed Al Ghobain,1,2 H Alhashemi,1,2 A Aljama,3 S Bin Salih,1,2 Z Assiri,4 A Alsomali,4 Gamal Mohamed5 1Department of Medicine, College of Medicine, King Saud Bin Abdulaziz University for bioglan deep sleep Health Sciences, 2King Abdullah International Medical Research Centre, 3Department of Medicine, King Abdulaziz Medical City, 4College of Nur